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Lymphatic endothelium : ウィキペディア英語版
Lymphatic endothelium
The lymphatic endothelium is a specialised form of epithelium, distinct from but similar to vascular endothelium. A lymph capillary endothelial cell is distinct from other endothelial cells in that collagen fibers are directly attached to its plasma membrane.
Although lymphatics were first described by Hippocrates in 400BC and rediscovered as "milky veins in the gut of a well fed dog" in the 17th century by Gasparo Aselli, they were ignored for centuries until in 1937 Howard Florey showed that lymphatics enlarge in inflammation. At this stage vascular and lymphatic endothelia were seen to be morphologically distinct and lymphatic vessels considered less important. Later it was discovered that VEGF-R3 and VEGF-C/VEGF-D were the key growth factors controlling lymphatic endothelial proliferation. Markers of lymphatic endolthelium were not discovered until relatively recently. These being LYVE-1 (Jackson et al.,1999)〔(【引用サイトリンク】 url = http://www.jcb.org/cgi/content/full/144/4/789?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=lyve-1&searchid=1&FIRSTINDEX=0&volume=144&issue=4&resourcetype=HWCIT )〕 and podoplanin (Kerjaschki,1999).〔(【引用サイトリンク】 url = http://ajp.amjpathol.org/cgi/content/full/154/2/385?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&titleabstract=Angiosarcomas+express+mixed+endothelial+phenotypes+of+blood+and+lymphatic+capill&searchid=1&FIRSTINDEX=0&firstpage=385&fdate=1/1/1999&tdate=12/31/1999&resourcetype=HWCIT )
==See also==
Endothelium

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Lymphatic endothelium」の詳細全文を読む



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